Problem+Set+6

Here is the ProblemSet #6 file. The on-line due date is 07-13-2010. Please download it, answer the questions assigned to your LG (LG-WX, LG from Worcester; LG-MX, LG from Manchester), and upload your answer file back accordingly (below). If you have any problems to upload your file back, please send your file directly to me at jonathan.sheng@mcphs.edu and l will do it for you. Each question will be answered by two LGs independently.

Question A.(1) LG-M4: Log P = 5 aliphatic (2.5) + 1 phenyl (2.0) + 1 CH3 (0.56) + 1 COOH (-0.7) = 4.3

LG-W4: Log P = 5 Aliphatic Carbons (2.5) 1 Phenyl Grp (2.0) 1 Methyl Grp (0.56) 1 Carboxyl Grp (-0.7) Log P =4.3

Question A.(2) Phenyl +2.0 Amine -1.0 Amide -0.7x2= -1.4 Sulfur 0 Chloride +0.5 Alkene C +0.33x2=+0.66 Carboxyl -0.7 Aliphatic C 0.5x4=+2.0
 * LG-M5**:

LogP= +2.06

LG-W5:

Question B. LG-M6: Aspirin: logP = 1.1, Carphenazine: logP = 4.8, Codeine: logP = 4, Cyproheptadine: logP = 7.5, Haloperidol: logP = 5.8, Chlordiazepoxide: logP = 2.5, Phenytoin: logP = 3.1

LG-W6: